Hi Sanskriti,
thank you for sharing this interesting case!
I have a question regarding the timeline of the process:
If the piles appeared in 2018, was this before he left his old job and started his own in november?
It seems to me that their appearance may be connected to his decision to leave and that this was a resolution to his territorial anger and identity conflict with his boss (the ((Digestive - Anal Mucosa (squamous epithelium)|rectum mucosa)) reacted with swelling and pain, you find these in the "cortex/ectoderm" sheet). But his self-doubts that he has carried for so long didn't resolve yet - while he is pushing himself, there is some weakening still going on in his tissues.
After this decision, he became entrepreneur and also alone responsible for his success, which of course was a new stress phase, this time rather "old brain" style. The big swelling could be interpreted as ((Digestive - Rectum - Mucosa (Endodermal layer)|submucosa)) in the anal region (chunk about holding on/ not letting go), or as the ((Urinary - Kidneys - Collecting Tubules|kidney tubules)) enlarging the oedema (abandonment/existence conflict). 

If he found a meaning in his struggles, he doesn't need to change his mindset regarding these. 
However, what I see is that he is pushing himself too hard, which impacts his lifestyle so that he doesn't value his own health. If he could find a way to not hold on that hard, and to take some time for motion between turns of sitting, this might help both his body and his brain to process his chunks easier! Movement and rhythm stimulate the brain hemispheres to more playfulness and creativity, they also help self-confidence and thereby, his success!
Do you think this might resonate with him?